口服酮康唑外用联苯苄唑凝胶对糠秕孢子菌性毛囊炎的疗效

Efficacy of Ketoconazole and Bifonazole for pityrosporum folliculitis

目的观察口服酮康唑加外用联苯苄唑凝胶对糠秕孢子菌性毛囊炎的临床疗效。方法 2009年6月—2011年11月我院收治200例糠秕孢子菌性毛囊炎患者,按随机数字表随机分为:实验组100例应用酮康唑加联苯苄唑凝胶治疗,对照组100例单用酮康唑治疗,治疗持续2周,随访1年。结果实验组治疗1周后总有效率(73%)高于对照组(43%)(P<0.05);治疗2周后,实验组总有效率为86%,高于对照组的63%,差异也有统计学意义(P<0.05);用药副作用差异无统计学意义(P>0.05),实验组1年后复发率1.2%低于对照组的11.1%,差异有统计学意义(P<0.05)。结论酮康唑加联苯苄唑凝胶能有效治疗糠秕孢子菌性毛囊炎,疗效满意。

Objective To observe the efficacy of Ketoconazole and Bifonazole for pityrosporum folliculitis. Methods A total of 200 patients with pityrosporum folliculitis, admitted to our hospital from June 2009 to November 2011, were divided into two groups by random number table. The trial group （n=100） was treated with oral Ketoconazole and external Bifonazole gel and the control group （ n = 100） with single Ketoconazole. The treatment continued for two weeks and the follow-up for one year. Results Of the trial group, the total efficiency was 73.0% after one week＇ s treatment, higher than that （43.0%） of the control group （P 〈0.05） ; af- ter two weeks＇ treatment, the rate of the trial group was 86.0%, still higher than that （63.0%） of the control group （P 〈 0.05 ）. The difference in medication side effects was not statistically significant between the two groups （ P 〉 0.05 ） ; the recurrence rate ot the trial group was 1.2% after one year, which waslower than that （ 11.1% ） of the control group （P 〈 0.05 ）. Conclusion Oral Ketoconazole combined with external Bifonazole gel can effectively treat pityrosporum folliculitis, and its therapeutic outcome is satisfactory.