猪O型口蹄疫母源抗体消长规律及疫苗免疫的干扰作用

Growth and Decline Laws of Maternal Antibodies of Swine O-type Foot and Mouth Disease and Its interference Effect on Vaccine Immunity

[目的]制定科学合理的免疫程序,从根本上控制仔猪O型口蹄疫的发生。[方法]采用ELISA抗体检测试剂盒对涪陵某规模化养殖场母猪和仔猪进行了母源抗体和免疫抗体检测。[结果]仔猪在10日龄左右抗体效价最高,平均效价为2.62。随着日龄的增长,仔猪母源抗体水平迅速下降至不完全保护水平。不同日龄首免仔猪口蹄疫疫苗免疫抗体检测结果表明母源抗体效价对试验猪的免疫应答有较大的影响。[结论]30～45日龄是仔猪接种FMD疫苗的最佳时间,这与母源抗体的消长规律相一致。

[ Objective] The research aimed to make scientific and reasonable immune procedure and control the occurrence of O-type foot and mouth disease of piglet radically. [ Method] The maternal antibodies and immune antibodies of sow and piglets in a large-scale pig farm of Fuling Region were detected by ELISA antibody detection kit. [ Result] The antibody titer of 10-day-old piglets was the highest and the average titer was 2.62. The maternal antibodies level of piglets quickly reduced to incomplete protected level with the day-old. The antibody detection results of piglets immunized with foot and mouth disease vaccine with different first immunization time showed that the titer of maternal antibodies had grea- ter influences on the immune response of test pigs. [Conclusion] The best time for inoculating piglets with FMD vaccine was 30 -45 d,which was accordant with the growth and decline laws of maternal antibodies.