重庆地区2010—2012年儿童鲍曼不动杆菌临床分布及耐药性分析

Clinical distribution and drug resistance analysis of Acinetobacter baumannii from children in Chongqing during 2010-2012

目的了解2010—2012年重庆地区儿童鲍曼不动杆菌的临床分布及对常见抗菌药物的耐药情况。方法收集2010—2012年临床分离的1 602株鲍曼不动杆菌,采用肉汤稀释法测定其对相应抗菌药物的最低抑菌浓度(MIC)值。结果 2010—2012年鲍曼不动杆菌均以痰标本分离率最高(85.08%,1 363/1 602);分离率居前3位的临床科室依次为新生儿科(29.21%,468/1 602)、呼吸科(18.79%,301/1 602)、重症监护病房(17.48%,280/1 602)。2010—2012年鲍曼不动杆菌对11种常用抗菌药物的耐药率各不相同,但耐药率均小于50.00%。碳青霉烯类抗菌药物耐药率呈上升趋势(P<0.05)。结论临床分离鲍曼不动杆菌耐药情况存在地域和人群差异,应加强对鲍曼不动杆菌的耐药性监测,合理使用抗菌药物。

Objective To investigate the distribution of Acinetober baumannii isolated from children in Chongqing during 2010-2012 and its resistance situation to common antibacterial agents.Methods 1 602 strains of Acinetober baumannii clinically isolated during 2010-2012 were collected and the broth dilution method was adopted to determine the minimal inhibi tory concentration（MIC） to the corresponding antibacterial agents.Results The highest isolation rate of Acinetober baumannii during 2010-2012 was from the sputum specimens（85.08%,1 363/1 602）;the top 3 places of isolated rates were the neonatology department（29.21%,468/1 602）,respiratory department（18.79%,301/1 602） and the intensive care unit（17.48%,280/1 602）.The resistant rates of Acinetober baumannii to 11 kinds of common antibacterail agents during 2010-2012 were different from each other,but which all were less than 50.00%.The resistance rate to carbapenems showed the increasing trend（P0.05）.Conclusion The drug resistance situation in clinically isolated Acinetobacter baumannii appears the area and population difference.Drug resistance monitoring of Acinetobacter baumannii should be strengthened in clinic,and antibacterial agents should be used more rationally.