妊娠高血压综合征患者凝血功能的变化分析

Analysis of the changes of coagulation function in patients with pregnancy induced hypertension syndrome

目的检测妊娠高血压综合征患者凝血功能相关指标,探讨妊高征患者的凝血状态。方法选择健康女性、正常妊娠孕妇、妊娠高血压综合征患者各150例,检测其血清凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fib)、凝血酶时间(TT),并进行统计学分析。结果与健康女性比较,正常妊娠组孕妇的PT、APTT均下降,TT、Fib升高,其差异均有统计学意义(P<0.05)。与健康女性比较,妊高征孕妇的PT、APTT、TT均下降,Fib升高,其差异均有统计学意义(P<0.05)。与正常妊娠孕妇比较,妊高征孕妇的PT、APTT、TT、Fib均下降,其差异均有统计学意义(P<0.05)。结论对妊高征患者进行凝血功能指标检测,对其病情的评估具有重要意义,更可以有效预防DIC的发生,具有重要价值。

Objective To test the related indexes of coagulation function in patients with pregnancy induced hyperten- sion syndrome, to explore the coagulation status. Methods Chose healthy women, pregnant women and pregnancy induced hypertension syndrome women. Tested prothrombin time （VT）, activated partial thromboplastin time （AFTT）, fibrinogen （Fib）, thrombin time （TT＇）, and the data were statistically analyzed. Results Compared with healthy women, normal pregnant wom- en PT, APTT decreased, TT, Fib increased, the difference was statistically significant （P〈0.05）. Compared with healthy wom- en,pregnancy induced hypertension women PT, APTI＇, TT decreased, Fib increased, the difference was statistically significant （P〈0.05）. Compared with the normal pregnant women,pregnancy induced hypertension women PT, AVTT, TT, Fib were de- creased, the difference was statistically significant （P〈0.05）. Conclusion Examining pregnancy induced hypertension pa- tients coagulation indexes can evaluate the severity of disease, can effectively prevent occurrence of DIC, it has important value.