他克莫软膏治疗慢性光化性皮炎的临床效果研究

Study on clinical effect of chronic actinic dermatitis treated with tacrolimus

目的探讨慢性光化性皮炎患者采用他克莫司进行治疗后的临床效果。方法本次的研究对象为2010年5月～2012年11月来我院进行治疗的慢性光化性皮炎患者140例,按照入院的先后顺序分为观察组和对照组各70例,对照组患者采用口服沙利度胺片进行治疗,观察组采用他克莫司进行治疗,采用统计学方法对结果进行分析比较。结果观察组与对照组比较,总显效率明显较高(P<0.05)。治疗2周后及治疗4周后观察组及对照组患者的症状/体征、瘙痒评分及DLQI评分与治疗前比较均出现明显的降低(P<0.05)。两组比较,观察组改善的程度更大(P<0.05)。结论慢性光化性皮炎患者采用他克莫司进行治疗能够收到较好的治疗效果,可以在临床推广应用。

Objective To explore the clinical effect of patients with chronic actinic dermatitis treated with tacrolimus. Methods One hundred and forty patients with chronic actinic dermatitis that were collected from 2010 May to 2012 Nov in our hospital, and divided into observation group and control group in accordance with the order of admission and there were 70 pa- tients in each group, the control group were treated by oral thalidomide, the observation group were treated with tacrolimus, used statistical to analyze and compared the results. Results The total effective rate in the observation group was significantly higher than that in the control group （P〈0.05）. The symptoms / signs, pruritus score and DLQI score in the observation group and the control group after 2 weeks of treatment and 4 weeks after the treatment were significantly decreased than before treat- ment（P〈0.05）. The observation group improved more than control group （P〈0.05）. Conclusion Patients with chronic actinic dermatitis with tacrolimus treatment can receive better treatment effect, can be widely used in clinical practice.