依那普利叶酸片降低血清同型半胱氨酸水平的疗效观察

Efficacy of enalapril folic acid tablet in lowering plasma homocysteine level in hypertension patietns

目的评价马来酸依那普利叶酸片用于原发性高血压患者降低同型半胱氨酸(Homocysteine Hcy)及降压的疗效及安全性。方法将入选的172例高血压患者随机分3组,依那普利组、马来酸依那普利叶酸10mg/0.4mg组和马来酸依那普利叶酸10mg/0.8mg组,于治疗前测定血压、Hcy。治疗后4、8周分别复测血压、Hcy,进行统计学分析。结果两种马来酸依那普利叶酸片均能有效降低Hcy水平,均显著优于依那普利组(P<0.05)。依那普利叶酸片各种不良反应发生率与依那普利类似。结论马来酸依那普利叶酸片可降低原发性高血压患者的血压和血清Hcy水平。

Objective To investigate the efficacy and safety of ernalapfil folic acid tablets in lowering blood pressure and plasma homocysteine（Hcy） levels in hypertension patients.Methods The 172 hypertension patients were divided into Group I treated with enalapril）,Group II treated with enalapril maleate folic acid tablet10mg/0.4mg aand group III treated with enalapril maleate folic acid tablet10mg/0.8mg）.The results were analyzed.Results The two enalapril maleate folic acid tablets could both lower the plasma homocysteine levels in hypertension patients and significantiy better than enalapril（P 0.05）.The adverse reactions of group II and III were similar to that of group I.Conclusions Enalapril maleate folic acid tablet can lower the blood pressure and the homocysteine level in essential hypertension patients..