脓毒症患者血清心肌酶学改变及其临床意义

Clinic significance of changes of serum myocardial enzymes in patients with sepsis

目的探讨脓毒症患者血清心肌酶学变化及其临床意义,以期为脓毒症治疗提供依据。方法选择2006~2011年确诊为脓毒症的患者53例为治疗组,另收同期非脓毒症患者32例为对照组。比较两组患者血清AST、LDH、CK、CK-MB水平。结果脓毒症组患者血清AST、LDH、CK、CK-MB水平均较对照组明显高（P〈0.05）,与APACHEⅡ评分数值呈明显正相关,且医治无效的脓毒症死亡组血清CK-MB与较存活组明显增高（P〈0.05）。结论脓毒症患者心肌酶学水平显著增高,CK-MB水平可作为判断脓毒症患者预后的重要指标之一。

Objective To observe the clinic significance of changes of serum myocardial enzymes in patients with sepsis.Methods 53 sepsis patients were selected as experimental group and 32 other patients with normal level of myocardial en zymes were categorized into as control group.The level of AST,LDH,CK and CK-MB were detected in patients of the two group from 2006 to 2008.Results The levels of serum myocardial enzymes such as AST,LDH,CK and CK-MB in experi mental group were higher than those in the control group（p0.05）.Positive correlation was shown between the level of serum myocardial enzymes and APACHEⅡscore.Conclusion The serum myocardial enzymes in the of patients with sepsis in creased significantly.The level of CK-MB may be the important indictor for prognosis of sepsis.