2012年西安地区幽门螺杆菌对几种常用抗生素的耐药分析

Analysis of Several Common Antibiotic Resistance of Helicobacter Pylori in Xi＇an in 2012

目的 探讨2012年西安地区120例幽门螺杆菌（Helicoba-cter pylori,H.pylori）阳性患者标本中,H.pylori对甲硝唑、克拉霉素、阿莫西林、左氧氟沙星的耐药情况,以指导临床用药.方法 收集2012年3月至2013年1月西安市中心医院将120例H.pylori阳性患者胃粘膜组织,接种于H.pylori选择性培养基,37℃微需氧环境培养3～5天,采用E-test法,筛选出耐药菌株.结果 120例标本H.pylori菌株培养阳性62例,H.pylori对甲硝唑、阿莫西林、克拉霉素、左氧氟沙星的耐药率分别为61.3%,6.5%,33.9%和25.8%.结论 2012年西安地区H.pylori对几种常用抗生素耐药率较之前有所升高,对甲硝唑耐药率比较高,对阿莫西林较高度敏感,药敏实验有助于抗生素的选择.

Objective To investigate the resistance to metronidazole, clarithromycin, amoxicillin and levofloxacin of 120 patients with H. pylori positive samples in Xi＇an,in 2012,to guide the clinical medication. Methods The gastric mucosal tissue was inoculated on H. pylori selective medium,be cultivated 3-5 days in micro aerobic environment with 37℃. The resistant strains were selected by E-test. Results There were 62 positive samples that were isolated successfully and＇the resistance rate to metronidazole was 61.3 %, to amoxicillin 6.5 % to elarithromycin 33. 9 %, to levofloxacin 25.8 %, respectively. Conclusion In Xi＇an city, the resistance rate of H. pylori was higher than before in 2012. Resistance to metronidazole was more common compared with others,and sensitive to amoxicillin,drug sensitive test is helpful to the choice of antibiotics.