神经元特异性烯醇化酶（NSE）在早期脑挫裂伤诊断中的意义

Diagnostic Value of NSE（Nuron Specific Enolase） in the Patients of Early Brain Contusion and Laceration

目的 探讨血清神经元特异性烯醇化酶（NSE）在早期脑挫裂伤患者诊断中的意义.方法 121例脑挫裂伤组患者早期（伤后12 h内）血清来源于陕西咸阳215医院脑挫裂伤患者,男性70例,女性51例,年龄18~67岁,平均年龄38.7岁,并脑挫裂伤患者均经CT或MRI检查明确诊断,其中轻型颅脑损伤73例,重型颅脑损伤48例.90例正常人群作为健康对照组,标本来自于健康体检人群,其中男性56例,女性34例,年龄19～60岁,平均年龄36.4岁,均排除肺部疾病及神经系统疾病.采用电化学发光法检测血清中NSE浓度,应用t检验进行统计学分析血清NSE水平在颅脑损伤患者与健康人群间的差异.结果 48例重型颅脑损伤组的NSE浓度为26.5±12.3 ng/L,73例轻型颅脑损伤组的NSE浓度为18.7±9.1 ng/L,90例健康对照组的NSE浓度为10.3±3.2 ng/L.对照组与轻、重型颅脑损伤组比较t值分别为2.986和3.152,P均〈0.01;轻、重型两组比较t=2.076,P〈0.05.121例脑挫裂伤患者早期NSE水平明显高于对照组.结论 血清神经元特异性烯醇化酶（NSE）水平检测可以作为早期脑挫裂伤诊断及评估伤情程度的辅助指标.

Objective To investigete the diagnostic value of NSE（nuron specific enolase） to the patients with early brain contusion and laceration. Methods Studying the investigation by contrasting different medical case of illness,90 specimen （56 male,34 female）were from healthy people who were not puzzled by lung disease and nervous system diseases,and the average age of them was 36 yearsold. In contrast, 121 specimen （70 male, 51 female） with early brain contusion and laceration were from the 215 hospital patients who were diagnosed by CT or MRI,the average age of which was 38.7 years old, the case includes mild head injury 73 patients, and 48 patients of severe traumatic brain injury. Using ECLIA to detect the NSE concentration of the serum,and Student t test was used for statistical analysis of serum NSE level differences in traumatic brain injury patients and healthy population. Results The NSE level of severe traumatic brain injury was 26.5 q-12.3 ng/L, and the NSE level of mild traumatic brain injury was 18.7=1=9.1 ng/L. In contrast,the NSE level of healthy population was 10.3d： 3.2 ng/L. The contrast value of t-test with the first case and the second case were 2. 986 and 3. t52 respectively,then P^0. 01. The value of t-test with the mild injury and the severe injury was 2. 076 （P〈0. 05）. Could conclude that the NSE level of 121 cases with early brain contusion and laceration was higher than the control group significantly. Conclusion NSE test can be regarded as an valuable quota in the diagnosis of brain contusion and laceration or estimate the degree of injury.