急性冠脉综合征患者肌钙蛋白和低密度脂蛋白氧化修饰延滞时间检测的临床意义

Clinical Significance of Analysis cTnI and Delay Time of ox-LDL in Acute Coronary Syndrome

目的 探讨肌钙蛋白（cTnI）和低密度脂蛋白氧化修饰期联合检测在诊断急性冠脉综合征（ACS）患者病变程度中的价值.方法 采用共扼双烯（CD）法测定低密度脂蛋白氧化修饰期,胶乳增强免疫比浊法测定cTnI,经检测ACS患者80例,其中急性心肌梗死（AMI）30例、不稳定性心绞痛（UAP）20例、稳定心绞痛（SAP）患者30例,并与正常对照组40例比较.结果 ACS不同病变程度组即急性心肌梗死组、不稳定性心绞痛组和稳定性心绞痛组患者与对照组cTnI含量和LDL氧化修饰期参数差异有统计学意义（t=10.24,15.48,22.49,P＜0.01;t=32.76,25.35,22.05,P＜0.01）.而急性心肌梗死组和不稳定性心绞痛组cTnI含量差异无统计学意义（t=0.879,P＞0.05）,LDL氧化修饰延滞时间在上述两组间差异有统计学意义（t=8.476,P＜0.05）.结论 ACS患者联合检测cTnI和LDL氧化修饰期的变化,可界定ACS病变程度.

Objective To discuss the significant of analysis cTnI and delay time of ox-LDL in acute coronary syndrome （ACS）. Methods Serum from 80 patients with acute eoronary syndrome,eluding in AMI 30 eases, UAP 30 cases,SAP 30 cases and 40 healthy controls, were determined cTnI and delay time of ox-LDL by CD methods and hematopexis equipment seperately. Results Patients with acute coronary syndrome （ACS） had higher eases of cTnI,lower level of delay time of oxLDL,than healthy controls （t= 10. 24,t= 15.48,t=22.49,P〈0.01;t= 32. 76,t=25.35,t=22.05,P〈0. 01）. However, the level in AMI and UAP had no difference （t=0. 879,P〈0. 05）. The difference of delay time in ox-LDL was significant between AMI and UAP （t=8. 476,P〈2005）. Conclusion cTnI and delay time of ox-LDL may be a useful factor for diagnosis acute coronary syndrome （ACS）.