血清维生素D水平与幼龄儿童社区获得性肺炎严重程度及危险因素的相关性研究

Correlation between serum vitamin D level and severity of community acquired pneumonia in young children

目的探讨幼龄儿童体内血清维生素D水平来分析其与社区获得性肺炎(CAP)严重程度的关系,并探讨CAP的相关危险因素。方法随机选取2011年10月至2012年4月就诊的CAP患儿103例为研究对象,其中重度CAP患儿15例,轻度CAP患儿88例;另随机选取同期门诊体检的健康儿童90例为正常对照组。采用酶联免疫法测定各组儿童体内25-(OH)D3的水平。结果重度组患儿血清25-(OH)D3水平显著低于轻度组和对照组(P<0.01),轻度组与对照组之间差异无统计学意义(P=0.674)。多因素回归分析提示25-(OH)D3水平<50 nmol/L和有早产史是重度CAP发生的独立危险因素。结论维生素D缺乏可能影响幼龄儿童CAP的严重程度。

Objective To study the correlation between serum vitamin D level and severity of community acquired pneumonia （CAP） in young children, and explore related risk factors for CAP. Methods One hundred and three children with CAP between October 2011 and April 2012 were enrolled in the study, including 15 cases of severe CAP and 88 cases of mild CAP. Ninety healthy children were used as the control group. 25-（OH） D3 concentrations were measured by enzyme linked immunoassay. Results The mean vitamin D concentration in the severe CAP group was significantly lower than in the mild CAP and control groups （ P 〈 0.01 ） , and there was no significant difference between the mild CAP and control groups （ P = 0. 674）. Premature birth and vitamin D 〈 50 nmol/L were risk factors for severe CAP in the multivariate analysis. Conclusions Vitamin D deficiency might be associated with the severity of CAP in young children.