利奈唑胺治疗儿童革兰氏阳性菌感染疗效的Meta分析

A Meta-analysis on outcomes of treating Gram-positive infection in children with linezolid

目的采用Meta分析比较利奈唑胺和万古霉素(或头孢羟氨苄)治疗儿童革兰氏阳性菌感染的临床疗效。方法检索Medline数据库、Embase数据库、Ovid数据库、Cochrane图书馆及中文生物医学期刊数据库等,收集利奈唑胺治疗儿童革兰氏阳性菌感染的随机对照试验文献,对照组为万古霉素或头孢羟氨卞,采用RevMan 5.0进行统计分析。结果共纳入合格文献5篇,患者1164例。利奈唑胺组临床治愈率与对照组相当[OR=1.54,95%CI(1.01-2.35),P=0.05];利奈唑胺组微生物清除率与对照组相当[OR=1.07,95%CI(0.62-1.83),P=0.81];利奈唑胺组不良反应少于对照组[OR=0.53,95%CI(0.33-0.86),P=0.01]。结论利奈唑胺疗效肯定,安全可靠。

Objective To compare the efficacy of linezolid and vancomycin（or cefadroxil） in the treatment of Gram-positive infection by Meta-analysis. Methods Data of treating childrenrs Gram- positive infection with linezolid （linezolid group） and vancomycin（or cefadroxil）（control group） were collected by searching the Medline database, Embase database, Ovid database, Cochrane library, and Chinese Biomedical Database. Randomized controlled trials were analyzed by RevMan 5.0 software. Results A total of 5 qualified literatures including 1164 cases was put into analysis. The clinial cure rate of linezolid group was similar to that of control group [OR= 1.54, 95%CI （1.01-2.35）, P： 0. 05]. So did the clearance rate[OR=1.07,95%CI（0. 62-1.83）,P=0. 813. Linezolid group had less adverse effects than control group[OR= 0. 53,95% 0CI（0. 33 0.86）, P=0. 01]. Conclusion The efficacy of treating Gram-positive infection with linezolid is definite, reliable and safe.