冠心病患者不同糖代谢对糖餐后甘油三酯的影响

Relationship between plasma triglyceride levels and glucose metabolism after oral glucose load in patients with coronary artery disease

评估冠心病患者75 g葡萄糖负荷后糖脂代谢变化.对237例冠心病患者行糖耐量试验,检测餐后2 h血糖、胰岛素及血脂.将患者根据空腹及OGTT 2 h血糖结果分为血糖正常组、糖耐量异常组及糖尿病组.冠心病患者中糖调节异常者占72.15%.冠心病患者糖餐后甘油三酯明显下降,与胰岛素水平及HOMA-IR相关.IGT组及糖尿病组空腹甘油三酯明显高于血糖正常组,服糖后2 h各组甘油三酯水平均下降,其中IGT组下降最为明显.表明冠心病患者糖餐后2 h甘油三酯水平可以作为胰岛素抵抗的新指标.

This paper observed the levels of plasma triglyceride and glucose after oral glucose load in patients with coronary artery disease （ CAD）. An oral glucose tolerance test （OGTT） was performed in 237 CAD patients, plasma lipids, glucose and insulin were quantified in fasting and postprandial samples. According to fasting and postprandial glucose level, pa- tients were divided into three groups, normal group, impaired glucose tolerance （IGT） group and diabetes mellitus （DM） group. The total prevalence of abnormal glucose metabolism was 72.15% in patient with CAD. The levels of plasma triglyceride decreased 2 h after glucose test. The change of the levels of plasma triglyceride between Oh and 2 h were strongly associ- ated with insulin levels and HOMA - IR. The levels of plasma triglyceride in DM and IGT group were significant higher than those in normal UA group （ 1.88 ± 1.71, 1.86 ± 1.28 vs 1.32±0.78, respectively） （P 〈0.05）. The levels of plasma triglyceride 2 h after glucose test in all groups were significant decreased, especially in IGT group. The observed decrease of triglycerides after glucose load in subjects with signs of insulin resistance suggests that post -glucose triglyceride change is a potential novel biomarker for early detection of metabolic risk.