多模式成像技术检测易损斑块

Non-invasive multi-modality imaging techniques in detection of vulnerable plaques

易损斑块的早期检测对预防其严重并发症(如急性冠状动脉综合征)至关重要。斑块的易损性主要取决于斑块的炎症状态。因此迫切需要一种既能反映斑块形态学特征又能体现斑块炎症程度的影像学手段。PET/CT和PET/MRI作为多模式成像技术,能够评价动脉粥样斑块炎症程度。本文就CT、MRI、PET/CT、PET/MRI检测冠状动脉粥样硬化易损斑块的研究进展进行综述。

Detection of vulnerable plaques on the early stage is of vital importance in the prevention of its dreadful compli- cations such as acute coronary syndrome. However, inflammatory cells and proteins play a key role in the progression of vulnerable plaques. So clinically, there is an urgent need for a kind of multi-modality imaging strategy which can both re- flect the characteristics of plaque morphology and plaque inflammation degree. PET/CT and PET/MRI are promising strat- egies in this regard, especially combined with CT or MRI, which provide not only the morphological characteristics, but al- so the inflammatory state of the atheromatous plaques. The progresses of CT, MRI, PET/CT, PET/MRI for detection of vulnerable plaques were reviewed in this article.