摘要
上皮-间质转化(EMT)是肿瘤侵袭和转移的首要步骤,对于EMT的研究将为靶向抗肿瘤治疗奠定基础。本文概述了EMT的发生过程和调控机制,对近年来口腔鳞癌中有关EMT研究的最新进展进行综述。
出处
《临床口腔医学杂志》
2013年第7期440-443,共4页
Journal of Clinical Stomatology
基金
国家自然科学基金项目(81260393)
教育部春晖计划合作项目(Z2012007)
内蒙古自治区自然科学基金项目(2013MS1132)
参考文献28
-
1J M Lee, S Dedhar, R Kalluri, et al. Thompson. The epithelial-mes- enchymal transition: new insights in signaling, development, and disease [J]. Journal of Cell Biology,2006,172 (7) : 973-981.
-
2A Voulgari,A Pintzas. Epithelial-mesenehymal transition in cancer metastasis:mechanisms, markers and strategies to overcome drug re- sistance in the clinic [J]. Bioehimicaet Biophysiea Aeta, 2009, 1796 (2) : 75-90.
-
3D Sarri'o, S M Rodriguez-Pinilla, D Hardisson, et al. Epithelial-mes- enchymal transition in breast eaneer relates to the basal-like pheno- type [J]. Cancer Res- eareh, 2008,68 (4) : 989-997.
-
4J C Tse,R. Kalluri. Mechanisms of metastasis: epithelial-to-mes- enchymal transition and contribution of tumor microenvironment [J]. Journal of Cellular Biochemistry, 2007, 101 (4) : 816-829.
-
5X Yang, B Pursell,S Lu, et al. Regulation of β4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial to-mesenchymal transition [J]. Journal of Cell Science,2009, 122 (14) : 2473-2480.
-
6A Soltermann,V Tischler,S Arbogast,et al. Prognostic significance of epithelial-mesenchymal and mesenchymal-epithelial transition protein expression in non-small cell lung cancer [JJ. Clinical Cancer Research, 2008, 14 (22):7430-7437.
-
7J von Burstin, S Eser, M C Paul, et al. E-cadherin regulates metasta sis of pancreatic cancer in vivo and is suppressed by a SNAIL/ HDAC1 / HDAC2 repressor complex[J]. Gastroenterology, 2009 137 (1):361-71, 371.el-5.
-
8J Y Shih, M F Tsai,T H Chang, et al. Transcription repressor Slug promotes carcinoma invasion and predicts outcome of patients with lung adenocarcinoma [J]. Clinical Cancer Research, 2005, 11 (22) : 8070-8078.
-
9E C Ferber, M Kajita, A Wadlow, et al. A role for the cleaved cyto- plasmic domain of E -eadherin in the nucleus[J]. Journal of Bio- logical Chemistry, 2008, 283 (19): 12691-12700.
-
10L Arce, N N Yokoyama, M L Water man. Diversity of LEF/TCF ac- tion indevelopment and disease[J]. Oncogene, 2006, 25 (57) : 7492- 7504.
同被引文献7
-
1Huang J, Yao X, Zhang J, et al . Hypoxia-induced downregu- lation of miRNA-93 promotes epithelial mesenchymal transi- tion in human renal cell carcinoma[J]. Cancer Sci, 2013, 104 (12):1609 -1617.
-
2Melo SA,Esteller M. Dysregulation of microRNAs in cancer: playing with fire[J]. FEBS Lett, 2010,585(13) : 2087-2099.
-
3Xia Y, Chen Q, Zhong Z, et al .Down regulation of miRNA-93 promotes the invasion of non-small cell lung cancer by targeting MTAI[J].Cell Physiol Biochem, 32(2):476-485.
-
4Mu YP,Su XL. Polymorphism in pre-miRNA-93contributes to hepatocellular carcinoma risk in a chinese population[J]. Med Oncol, 2012,29(3):1723- 1732.
-
5白黎露,姚宏,张海军,李建学,马东洋.microRNA在口腔鳞癌中的研究进展[J].现代生物医学进展,2014,14(16):3163-3166. 被引量：4
-
6谢舒乐,杨宏宇.TGF-β信号通路与口腔鳞状细胞癌的研究进展[J].中华口腔医学研究杂志（电子版）,2014,8(3):61-64. 被引量：2
-
7刘思玉,谢龙,祁兵,马长艳,桑磊,李宏卫.口腔鳞状细胞癌组织中差异微小RNA/mRNA表达谱的对接研究[J].华西口腔医学杂志,2014,32(4):400-403. 被引量：14
-
1李媛媛,吴洪娟,卞海燕,刘雨清.COX-2和CD44v6在子宫内膜癌中的表达及其意义[J].中国现代医学杂志,2010,20(19):2930-2932. 被引量：4
-
2李曦,唐滔.环氧合酶-2在大肠癌中的调控机制[J].国外医学（消化系疾病分册）,2002,22(2):90-92.
-
3张蕾,温洪涛,张云汉.端粒酶的调控在肿瘤治疗中的启示[J].医学与哲学,2000,21(12):32-34.
-
4李登举,张瑶珍,曹文静,孙岚,张东华,徐慧珍,路武.端粒酶活性在白血病细胞凋亡中的变化及调控机制研究[J].中华血液学杂志,2002,23(7):376-377. 被引量：2
-
5童强松,曾甫清,鲁功成.膀胱肿瘤血管生成的研究进展[J].国外医学（泌尿系统分册）,2000,20(2):57-60. 被引量：1
-
6崔珍,彭开桂,沈学明,江浩,李多杰,汪庚明.Ezrin蛋白在食管鳞癌中的表达及其临床意义[J].蚌埠医学院学报,2009,34(7):576-578. 被引量：1
-
7崔珍,彭开桂,沈学明,江浩,张亚军,李红伟,何斌.E-钙黏蛋白在食管鳞癌中的表达及其临床意义[J].蚌埠医学院学报,2010,35(5):448-450. 被引量：2
-
8高庆,吴秉铨.基质金属蛋白酶与肿瘤侵袭和转移[J].中华病理学杂志,1998,27(2):155-156. 被引量：40
-
9木本安彦,田口铁南,佟富中,王大庆.LAK细胞的抗肿瘤治疗[J].国外医学（免疫学分册）,1989,12(5):255-257.
-
10简哲,盛钰琦,姜勇.miRNA、mRNA在乳腺癌中的作用[J].智慧健康,2016,2(3):44-47. 被引量：2
