模式识别受体介导的自噬在抗病原微生物感染中的研究进展

Pattern-recognition receptor-mediated autophagy in defense against pathogens

自噬作为机体自我保护的生理学行为,在抗病原微生物感染中发挥重要的免疫防御作用。模式识别受体通过诱导自噬的发生,加强对病原微生物的识别和清除能力。同时,自噬也可影响模式识别受体信号通路,负性调控炎症反应。除了TLRs(TOLL-like receptors)外,随着SLRs(sequestasome-like receptors)、NLRs(NOD-like receptors)、RLRs(RIG-like receptors)等新型或重要模式识别受体介导的自噬在机体抗病原微生物感染的作用相继被报导,人们对模式识别受体介导的自噬在抗病原微生物感染中作用的认识越来越深入和丰富。了解此方面的研究进展,对揭示病原微生物的致病机理、发展新的有效的抗感染治疗手段具有重要的理论指导意义。

Autophagy, as behavior of self-protective physiology process, plays a crucial role in defense against intraeellular pathogens. Pattern recognition receptors （PRRs） can mediate autophagy, and enhances recognition and elimination of intracellular pathogens. Meanwhile, autophagy negatively regulates PRRs-indueed inflammation. In addition to TLRs （TOLL-like receptors）, accumulating evidence has implicated that other PRRs, like SLRs （sequestasome-like receptors）, NLRs （NOD-like receptors）, RLRs （RIG-like receptors）, can also mediate autophagy. However, the mechanism underlying the regulation of autophagy by PRRs is poorly understood. This review traces the recently key findings about PRRs and autophagy.