虱目裂化线粒体基因组研究进展

Understanding mitochondrial genome fragmentation in parasitic lice(Insecta:Phthiraptera)

虱目是哺乳类和鸟类体表的专性寄生虫。在虱科、阴虱科、长角鸟虱科和兽羽虱科的某些寄生虱种中发现了线粒体基因组裂化现象,其线粒体基因组裂化成了多个环状的线粒体染色体,如体虱(Pediculushumanus)、头虱(pediculus capitis)和阴虱(Pthirus pubis)的线粒体基因组分别裂化形成20个、20个和14个微环染色体。微环染色体可能是基因删除和同源重组的结果,关于线粒体基因组裂化的具体原因和机制,目前并不清楚,推测可能是进化选择或随机遗传漂变的结果或与线粒体单链DNA结合蛋白的缺失有关。鉴于线粒体基因组裂化研究对于深入理解线粒体的起源和进化方面具有重要意义,文章以虱目裂化线粒体基因组为主线,列举了动物裂化线粒体基因组和裂化特征,阐述了虱目裂化线粒体基因组的研究现状,分析了虱目线粒体基因组裂化的类型、原因和机制,并对该领域未来的研究方向进行了展望。

Lice are obligate ectoparasites of mammals and birds. Extensive fragmentation of mitochondrial genomes has been found in some louse species in the families Pediculidae, Pthiridae, Philopteridae and Trichodectidae. For example, the mt genomes of human body louse （Pediculus humanus）, head louse （Pediculus capitis）, and public louse （Pthirus pubis） have 20, 20 and 14 mini-chromosomes, respectively. These mini-chromosomes might be the results of deletion and recombination of mt genes. The factors and mechanisms of mitochondrial genome fragmentation are currently unknown. The fragmentation might be the results of evolutionary selection or random genetic drift or it is probably related to the lack of mtSSB （mitochondrial single-strand DNA binding protein）. Understanding the fragmentation of mitochondrial genomes is of significance for understanding the origin and evolution of mitochondria. This paper reviews the recent advances in the studies of mitochondrial genome fragmentation in lice, including the phenomena of mitochondrial genome fragmentation, characteristics of fragmented mitochondrial genomes, and some factors and mechanisms possibly leading to the mitochon- drial genome fragmentation of lice. Perspectives for future studies on fragmented mt genomes are also discussed.