微小RNA在骨髓增生异常综合征中的异常表达及临床意义
摘要
骨髓增生异常综合征（MDS）是一组异质性造血干细胞克隆性疾病，以血细胞发育异常和病态造血，高风险向白血病转化为特征，MDS的发病机制尚不明确，研究表明基因缺陷蓄积在受影响祖细胞的凋亡、分化及增殖调节过程中起关键作用。根据WHO分型标准，MDS被分为不同亚型，具有不同特征及预后，有难治性贫血（RA）、难治性贫血伴环状铁粒幼细胞（RARS）、难治性血细胞减少伴多系发育异常（RCMD）、难治性血细胞减少伴原始细胞增多（RAEB-1和RAEB-2）、不能分类的MDS（MDS—U）及5q一综合征，MDS危险评估和预后根据国际预后积分系统（IPSS）确定，分为低危。
出处
《中华医学杂志》
CAS
CSCD
北大核心
2013年第28期2253-2256,共4页
National Medical Journal of China
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