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DLK1/GTL2印记基因甲基化状态及DLK1蛋白的表达与肿瘤

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摘要 DLK1/GTL2是一对重要的连锁印记基因,位于14q32。GTL2基因是一个母源性印记基因,其转录产物为非编码RNA。DLK1基因属父源性印迹基因。编码蛋白质DLK1,其表达程度的变化与某些肿瘤有关。作者从DLK1/GTL2甲基化状态的变化和DLK1蛋白的表达两个方面与肿瘤的关系做一综述。
作者 李健 叶定伟
出处 《现代泌尿外科杂志》 CAS 2013年第4期412-413,共2页 Journal of Modern Urology
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  • 1Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin, 2008, 58(2): 71-96.
  • 2Herbst RS, Heymach JV, Lippman SM. Lung cancer. N Engl J Med, 2008,359(13): 1367-1380.
  • 3Witschi H, Espiritu I, Peake JL, et al. The carcinogenicity of environmental tobacco smoke. Carcinogenesis, 1997, 18(3): 575-586.
  • 4Laborda J. The role of the epidermal growth factor-like protein dlk in cell differentiation. Histol Histopathol, 2000, 15 (1): 119-129.
  • 5Yin D, Xie D, Sakajiri S, et al. DLKI: increased expression in gliomas and associated with oncogenic activities. Oncogene, 2006, 25(13): 1852-1861.
  • 6Huang J, Zhang X, Zhang M, et al. Up-regulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma. Carcinogenesis, 2007, 28(5): 1094-1103.
  • 7Jin ZH, Yang RJ, Dong B, et al. Progenitor gene DLK1 might be an independent prognostic factor of liver cancer. Expert Opin Biol Ther, 2008, 8(4): 371-377.
  • 8Kawakami T, Chano T, Minami K, et al. Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma. Hum Mol Genet, 2006, 15(6): 821-830.
  • 9Lingfei K, Pingzhang Y, Zhengguo L, et al. A study on p16, pRb, cdk4 and cyclinD 1 expression in non-small cell lung cancers. Cancer Lett, 1998, 130(1-2): 93-101.
  • 10PapayJ, Krenacs T, MoldvayJ, et al. Immunophenotypic profiling of nonsmall cell lung cancer progression using the tissue microarray approach. Appl Immunohistochem Mol Morphol, 2007, 1S (1): 19-30.

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