表现为硬皮病样改变的肾源性系统性纤维化

Nephrogenic systemic fibrosis presented as scleroderma-like changes

报告1例表现为硬皮病样改变的肾源性系统性纤维化。患者男,55岁。双手及前臂、胸部及腹部色素沉着性肿硬斑块,临床表现与硬皮病相似,组织病理显示真皮内胶原纤维增生,患者并发有肾功能不全,诊断为肾源性系统性纤维化,经过8个月治疗皮损好转。

Nephrogenic systemic fibrosis is a fibrosing disorder that affects patients with advanced renal dysfunction. It can involve muhiple organ systems and its clinical manifestations vary. considerably. We report a case of a patient who presented with thick, indurated hyperpigmented plaques on the bilateral upper extremities, chest and abdomen. The clinical features were similar to scleroderma. Histopathological examination showed a marked increase in dermal collagen fibers. Patient had renal dysfunction. The patient was diagnosed as nephrogenic systemic fibrosis. After eight months＇ treatment, the patient had great improvement.