非典型阴茎雀斑样痣

Atypical penile lentigo:a case report and review of the literature

报告1例非典型阴茎雀斑样痣。患者男,24岁。龟头黑斑6个月余,逐渐增大。皮肤科检查:龟头左侧近阴茎包皮系带处一枚约1 cm×1 cm黑斑,境界清楚,表面光滑,无浸润及压痛。组织病理示表皮轻度角化过度,表皮突伸长呈杵状,棘层肥厚,表皮中上部可见少量异形的黑素细胞,基底层黑素明显增多,黑素细胞数量增加,个别细胞异形,真皮内可见噬黑素细胞,免疫组化示HMB-45(+),S-100蛋白(+),诊断为非典型阴茎雀斑样痣。

A 24-year-old male with atypical penile lentigo is reported. He p^sented with an asymptomatic pigmented lesion on the glans perlis for more than 6 months. The lesion had been increasing in size gradually. On the examination, the patient showed a well-demarcated hyper-pigmented macule in size of 1 cm × 1 cm with a smooth surface and no tenderness or sign of invasion. Histology of lesional specimen showed basal cell layer hyper-pigmentation with melanoeytic hyperplasia, elongation of the rete ridges, and slight epidernlal hyperkeratosis and acanthosis. A few of heterotypic melanocytes were seen in superficial and middle epidermis. The dermis eontained some large melanophages, hnmunohistochemieal staining showed positive for HMB-45 and S-100. A diagnosis of atypical penile lentigo is finally made.