重症急性胰腺炎患者QT间期离散度的临床意义

The clinical significance of QT interval dispersion in severe acute pancreatitis

目的探讨QT间期离散度（QT interval dispersion，QTd）对重症急性胰腺炎（severe acute pancreatitis，sAP）患者早期心脏损害的诊断价值及其预后判断意义。方法对收治具有完整心电图资料的58例SAP（SAP组）及189例轻型急性胰腺炎（MAP组）患者资料进行回顾性分析，另选60例门诊健康体检者的心电图作为健康对照组。分别测定12导联心电图QT间期，并计算QTd、心率校正OTd（heart rate correctedQTd，QTcd）。结果SAP组较MAP组及健康对照组QTd、QTcd显著延长（P〈0．01），MAP组较健康对照组QTd、QTcd无明显延长（P〉0．05）。结论QTd、QTcd对SAP患者的早期心脏损害有较大诊断价值，对SAP患者的预后也有较大帮助，可作为评价SAP患者心功能状态的一项辅助指标。

Objective To assess the clinical significance of QT interval dispersion （QTd） in the diagnosis and prognosis of early heart damage in patients with severe acute pancreatitis. Methods All patients received complete ECG, There were 58 patients with SAP （the SAP group） and 189 patients with mild acute pancreatitis （the control group）. These patients were analyzed retrospectively and 60 normal people were used as the healthy control group. The QT interval were measured respectively in serial 12-lead electrocardiogram and QTd, QTcd were calculated. Result QTd and QTcd were signif- icantly longer in the SAP group than in the MAP group and in the healthy control group （P〈0.01）. QTd, QTcd were not remarkably extended in the MAP group than in the healthy control group （P〈0.05）. Conclusions QTd and QTcd have clinical values to diagnose and to predict early heart damage in patients with SAP. They might be useful in evaluating the condition of cardiac function in patients with SAP.