复合溶葡萄球菌酶消毒剂治疗烧伤创面革兰阳性球菌感染

Effect of compound lysostaphin disinfectant in treatment of gram-positive coccus infection of burn wounds

目的比较复合溶葡萄球菌酶（Fudanenzyme，FE）消毒剂（百克瑞）和传统消毒剂碘伏防治烧伤创面革兰阳性（G＋）球菌感染的疗效。方法收集60例浅Ⅱ度烧伤患者（烧伤面积1％～5％，年龄18—50岁），每例患者治疗前创面取分泌物做细菌培养，其中20例培养出金黄色葡萄球菌（ staphylococcus aureus, SA），按随机数字表法分为对照组和试验组，每组10例。20例培养出表皮葡萄球菌（staphylococcusepidermidis，SE），按随机数字表法分为对照组和试验组，每组10例。20例培养出肠球菌（enterococcus，EC），按随机数字表法分为对照组和试验组，每组10例。试验组用百克瑞浸透4层无菌纱布外敷创面换药，对照组用碘伏浸透4层无菌纱布外敷创面换药，均每日换药1次，治疗5d期间每天每例患者创面取分泌物培养。比较各组患者的愈合情况。结果经过5d治疗后，SA感染创面，试验组10例全部转阴，对照组3例转阴（P〈0．01）。SE感染创面，试验组10例全部转阴，对照组6例转阴（P〈0．05）。EC感染创面，试验组9例转阴，对照组7例转阴（P〉0．05）。试验组平均愈合时间为（10．87±1．93）d，对照组为（13．31±2．89）d（P〈0．05）。结论百克瑞能有效防止烧伤创面常见G＋球菌感染，并能促进创面愈合。

Objective To compare the effect of Baikerui compound lysostaphin （FE complex phosphoesterasum） disinfectant and povidone iodine in treatment of burn wound infection resulted from gram-positive （G ＋ ） coccus. Methods The study involved 60 patients with superficial second degree burns （1%-5% TBSA; age range of 18-50 years）. M1 the patients received bacterial culturing of wound secretions prior to treatment. Every 20 patients were indentified with infection of staphylococcus aureus （SA）, staphylococcus epidermidis （SE）, and enterococcus （EC） respectively and randomized into control group and experiment group, with 10 patients per group. Patients allocated to the experiment group were covered with four-layer sterile gauze soaked into the Baikerui compound lysostaphin disinfectant, while the patients in the control group were treated with four-layer sterile gauze soaked into the povidone iodine. Dressing was changed once a day. Wound culturing was performed again at each day of the 5 - day treat- ment. Wound healing was compared among each group. Results SA wound infection turned negative for all the 10 patients in experimental group and three patients in control group （P 〈0. 01 ）. SE wound infec- tion turned negative for all the 10 patients in experimental group and six patients in control group（ P 〈 0. 05 ）. EC wound infection turned negative for nine patients in experimental group and seven patients in con- trol group （ P 〉 0.05 ）. Mean wound healing time was （ 10.87 ± 1.93 ） days for experimental group and （13.31 ± 2.89） days for control group （P 〈 0.05 ）. Conclusion Baikerui compound lysostaphin disin- fectant can effectively prevent burn wound infection with common G ＋ coccus and accelerate wound healing.