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ACE基因多态性及MYBPC3突变与高血压左室肥厚的关系 被引量：2

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摘要 目的探讨血管紧张素转换酶(ACE)基因多态性与肌球蛋白结合蛋白C(MYBPC3)基因突变联合作用和高血压左室肥厚(LVH)的关系。方法随机选取118例高血压LVH患者、238例高血压非LVH患者及104例血压正常对照者,行病例-对照研究。超声心动图测量和计算左室重量指数(LVMI);聚合酶链反应(PCR)、限制性片段长度多态性(RFLP)检测ACE/ID多态性;双脱氧末端测序方法检测MYBPC3基因突变。结果高血压LVH组ACE基因DD型频率显著高于高血压非LVH组和正常对照组(χ2=13.10,P<0.01);MYBPC3基因未发现突变。结论 ACE基因多态性与高血压LVH形成有关,DD基因型易发生LVH;MYBPC3基因突变与高血压LVH无明显关系;ACE基因DD型与MYBPC3基因间不存在联合作用。
作者 张猛 郭军霞 甘立军 李传方 高东升
机构地区 济宁医学院附属医院心内科 山东大学医学院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2013年第13期3027-3029,共3页 Chinese Journal of Gerontology
基金 山东省教育厅科技计划项目(No.J11LF59)
关键词 高血压 左心室肥厚 基因多态性 基因突变
分类号 R544.1 [医药卫生—心血管疾病]
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参考文献9

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共引文献9

同被引文献11

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中国老年学杂志
2013年 第13期

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