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趋化因子Fractalkine与老年常见疾病的关系 被引量:4

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摘要 不规则趋化因子〔Fractalkine(Fkn,CX3CL1)〕是一种兼有黏附和趋化活性的趋化因子;为7~15 kD的分泌型蛋白质,能趋化和激活白细胞而参与炎症反应的各个阶段,包括黏附、迁移、清除致炎物质、修复等;趋化因子分为4个亚族,即C、CC、CXC和CX3C,而人的Fkn因子是CX3C族中唯一已知的超家族成员,
作者 殷菱 李法琦
出处 《中国老年学杂志》 CAS CSCD 北大核心 2013年第13期3265-3268,共4页 Chinese Journal of Gerontology
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参考文献37

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二级参考文献91

  • 1陈小菊,程德云,杨莉,夏秀琼,苏巧俐.缺氧大鼠血清和肺内fractalkine的变化[J].中华结核和呼吸杂志,2006,29(1):54-55. 被引量:9
  • 2王蕾,王刚,李廷谦,向国霞.参芪扶正注射液对内毒素致急性肺损伤大鼠肺组织Fractalkine表达的影响[J].中国中西医结合杂志,2007,27(1):55-59. 被引量:10
  • 3Bazan JF, Bacon KB, Hardiman G, et al. A new class of membrane -bound chemokine with a CX3C motif[ J]. Nature, 1997,385 (6617) :640 -644.
  • 4Harrison JK, Fong AM, Swain PAW, et al. Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion [ J ]. J Biol Chem, 2001,276 ( 24 ) :21632 - 21641.
  • 5Foussat A, Coulomb - LHermine A, Gosling J, et al . Fractalkine receptor expression by T lymphocyte subpopulations and in vivo production of fractalkine in human [ J ]. Eur J Immunol, 2000,30 (1) :87-97.
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  • 7Lucas AD, Chadwick N, Warren BF, et al . The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo[ J]. Am J Pathol,2001,158(3) : 855 - 866.
  • 8Combadiere C, Salzwedel K, Smith ED, et al. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV21 [ J]. J Biol Chem, 1998,273 ( 37 ) : 23799 - 237804.
  • 9Eva Efsen, Cecilia Grappone, Raffaella MS, et al. Up - regulation expression of fractalkine and its receptor CX3CR1 during liver injury in humans [ J ]. J Hepatol,2002,37 ( 1 ) : 39 - 47.
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