肝细胞癌中microRNA对细胞凋亡、转移和周期的调控作用

Regulatory effect of miRNAs on apoptosis,migration,and cell cycle of hepatocellular carcinoma cells

microRNA(miRNA)是一类由内源基因编码的长度约为22个核苷酸的非编码单链RNA分子,参与转录后基因表达调控。大量证据显示一些miRNA在肝细胞癌(HCC)中表达失调,且发现miRNA通过一些通路或基因调控癌细胞的增殖、凋亡、转移、侵袭和细胞周期。另外,也有一些研究认为miRNA是癌基因或抑癌基因。因此,深入的了解miRNA在HCC中的具体作用和功能,或许会为HCC的治疗提供新的途径。

MicroRNAs （miRNAs） are a class of non - coding single - stranded RNA molecules of about 22 nucleotides in length that are en- coded by endogenous gene and participate in post - transcriptional regulation of gene expression. Many evidences indicate that some miRNAs are deregulated in hepatocellular carcinoma （HCC） , and it has been found that miRNAs regulate the proliferation, apoptosis, migration, in- vasion, and cell cycle of HCC cells through some pathways or genes. In addition, some studies suggest that miRNAs function as oncogenes or anti - oncogenes. Therefore, in - depth understanding of the specific role and function of miRNAs in HCC may provide a new approach for the treatment of HCC.