微颗粒与急性冠脉综合征

Microparticles and acute coronary syndrome

冠心病是目前世界上重要的死亡原因,给社会带来了沉重的负担。近年来,随着老龄化的到来,我国冠心病的发病率和死亡率迅速上升,所带来的社会和经济负担亦将进一步加重。急性冠脉综合征（acute coronary syndrome,ACS）是冠心病的一种较为严重的临床表现形式,具有较高的死亡率。ACS的发生与冠脉内斑块糜烂及破裂、血栓形成、血管痉挛等多因素导致急性或亚急性心肌供氧减少相关。一般认为,应激、炎症等导致血管内皮细胞损伤,引起斑块糜烂、破裂,血栓形成,引发ACS。

Coronary heart disease（CHD） is an important cause of death in the world.Among them,acute coronary syndrome（ACS） is a type of CHD that has a high mortality rate.Microparticles（MPs） are tiny particles formed in the process of cell activation and apoptosis,carrying specific markers of their mother cells.There is more and more evidence that MPs derived from endothelial cells,platelets,white blood cells and other cells are closely related to the formation of ACS.Through a variety of pathways,they take part in endothelial cell damage,vascular dysfunction,plaque erosion and rupture,and thrombosis.The findings of MPs enrich our knowledge about ACS,and may provide a new approach to the treatment of ACS.