西比灵联合川芎嗪治疗椎-基底动脉供血不足性眩晕68例临床效果分析

Analysis of the clinical effect of sibelium combined with ligustrazine on 68 cases of vertebral-basilar ischemic vertigo

目的探讨西比灵联合川芎嗪治疗椎-基底动脉供血不足性眩晕的临床疗效,为科学用药提供依据。方法回顾性分析在我院接受治疗的136例病椎-基底动脉供血不足性眩晕患者的临床资料,并在尊重其个人意愿的基础上将其分为西比灵组68例和联合治疗组68例。西比灵进行为期14d,1天1次,1次10mg的口服西比灵胶囊进行治疗;联合治疗组在西比灵治疗的基础上进行为期14d,1次/d,1次200mg的川芎嗪注射液的静脉滴注治疗。对两种治疗方法的临床疗效和安全性进行比较。结果联合治疗组的临床总有效率明显高于西比灵组,其临床总有效率可高达91.17%,差异具有统计学意义(P<0.05)。联合治疗组的安全性(高达97.06%)优于西比灵组,差异有统计学意义(P<0.05)。结论在治疗椎-基底动脉供血不足性眩晕的临床应用上,西比灵联合川芎嗪的疗效显著,是一种值得在临床上大力推广的联合治疗方案。

Objective To discuss the clinical effect of sibelium combined with ligustrazine on vertebral-basilar ischemic vertigo（VBIV）, and to provide scientific direction for drug application. Methods 136 cases of VBIV patients who were admitted into our hospital were retrospectively analyzed and were divided into sibelium group（68 cases） and combined treating group（68 cases） on the basis of respecting personal willingness.The sibelium group was treated with sibelium capsule 10rag at a time/d,the treatment course was 14 d,while the combined treating group was treated with ligustrazine injection 200mg at a time/d by intravenous drip.The clinical effect and safety of two methods were comparatively analyzed. Results The total clinical effect of combined treating group reached to 91.17%,and was obviously higher than sibelium group（P 〈 0.05）.Meanwhile,the safety value of combined treating group reached to 97.06%,and was superior to sibelium group （P 〈 0.05）.Conclusion As a combined treating method,sibelium combined with ligustrazine has a good effect on VBIV clinical therapy,it worth to be vigorously promoted in clinical treatment.