小儿破伤风应用静脉丙种球蛋白的免疫力效果观察

Observation on immune effect of intravenous immune globulin in the treatment of pediatric tetanus

目的为了进一步提高我院治疗小儿破伤风的临床疗效,保障患儿的生命安全,本资料就小儿破伤风应用静脉丙种球蛋白的免疫力的具体临床效果进行了浅显的研究和探讨。方法将我院在2010年10月～2012年12月期间收治的28例破伤风患儿随机分为观察组和对照组,两组患者均14例、给予对照组患儿采用破伤风抗毒素进行常规治疗;给予观察组患儿在常规治疗的基础上加用静脉丙种球蛋白进行治疗,对两组患儿的治疗效果进行观察和统计。结果两组患儿在接受治疗后,观察组患儿的治疗效果要明显的优于对照组患儿的治疗效果,两组之间的差异有统计学意义(P<0.05)。结论破伤风对患儿自身的免疫功能造成不小的影响,在常规治疗的基础上给予患儿静脉丙种球蛋白治疗小儿破伤风的临床效果十分显著,有效的提高了临床疗效,保障了患儿的生命安全,降低了疾病对患儿带来的痛苦,值得推广。

Objective To preliminarily study and discuss the specific clinical effect of intravenous immune globulin in the treatment of pediatric tetanus, in order to increase the clinical effect of treatment to the pediatric tetanus and guarantee their life safety. Methods 28 pediatric patients with tetanus treated in this hospital from October 2010 to December 2012 were randomly divided into the observation group and control group, including 14 cases in each group. Pediatric patients in the control group received the routine treatment of tetanus antitoxin; while pediatric patients in the observation group received the routine treatment and intravenous immune globulin. Observed and made statistics for the clinical effect of pediatric patients in two groups. Results After receiving the treatment, the clinical effect in the observation group was significantly better than the one in the control group, with the significant difference （P 〈 0.05）. Conclusion Tetanus has a great impact On the immune function of pediatric patients. Based upon the routine treatment, the intravenous immune globulin will have a significant clinical effect in the treatment to pediatric tetanus, which will significantly increase the clinical effect, guarantee patients＇ life safety, reduce the pains of disease to them and thus is worthy to be propularized.