帕罗西汀治疗焦虑抑郁症并功能性消化不良的疗效分析

Therapeutic Effects of paroxetine on anxiety and depression in patients with functional dyspepsia

目的探讨焦虑抑郁症患者并功能性消化不良的药物干预治疗及临床疗效分析。方法收集2012年4月至2013年1月在我院门诊或住院部病例125例,随机分为A组(治疗组)、B组(对照组),A组62例、B组63例,两组根据焦虑抑郁量表评分值再分为两个亚组:轻中度组、重度组。A组给予帕罗西汀治疗;B组给予帕罗西汀+奥美拉唑肠溶胶囊、莫沙必利治疗,分别于药物治疗后1、2、3月进行对比分析。结果焦虑抑郁症状呈轻中度病例,药物治疗后各时间点A、B组间有效率差别无统计学意义,P>0.05;而同组不同时间点有效率比较差别有统计学意义,P<0.05。焦虑抑郁症状呈重度病例,药物治疗后两组间各时间点有效的差别无统计学意义P>0.05,而同组不同时间点有效率比较也无统计学差异P>0.05。结论单用抗焦虑抑郁药物帕罗西汀治疗焦虑抑郁症合并功能性消化不良的疗效等同于帕罗西汀联合奥美拉唑肠溶胶囊、莫沙必利的疗效。

Objective To study the clinical effects of paroxetine on anxiety and depression in patients with functional dyspepsia. Methods One hundred and twenty-five patients were collected between April 2012 and Jan 2013. The patients were divided into two groups： treatment group（group A） and control group（group B）. Based on the score value of anxiety and depression scale, each group was further divided into two subgroups： mild or moderate group, and severe group. The patients in group A were treated with paroxetine, and in group B were treated with paroxetine,omeprazole, and mosapride. The clinical effects were analyzed at 1, 2, and 3 months after medicines were given. Results The effective rates on anxiety and depression of mild or moderate cases were no statistically significant differences between two groups （P0.05）, but between different time points the effective rates are statistically significant differences with P0.05. And the effective rates of severe cases wre no statistically significant differences between two groups at different time points （P0.05）. Conclusion The effective rates are the same between two treatment groups on anxiety and depression in patients with functional dyspepsia.