摘要
目的:观察FOLFOX 4与FLP化疗方案在晚期胃癌患者化疗中的疗效和毒副反应。方法:选取2011年1月—2012年9月我院的117例晚期胃癌住院患者,并均经病理确诊。FOLFOX 4方案:奥沙利铂(L-OHP)85mg/m2静滴,d1;氟尿嘧啶(5-FU)400mg/m2静推,600mg/m2持续静滴22h,d1～2;亚叶酸钙(LV)200mg/m2静滴2h,d1～2;3周为1个周期。FLP方案:顺铂(DDP)30mg/m2静滴,d1～3;5-FU 500mg/m2静滴4h,d1～5;LV200mg/m2静滴2h,d1～5;3周为1个周期。观察和比较FOLFOX 4与FLP两组的完全缓解情况和功能改善及毒副反应情况。结果:FOLFOX 4方案的总有效率为55.17%,FLP方案的总有效率为52.54%,两者无统计学差异(P>0.05)。两种化疗方案在改善患者的功能状态方面无差异(P>0.05)。FOLFOX 4方案组的神经毒性的发生率高于FLP组,而恶心呕吐的消化道反应的发生率明显低于FLP组(P<0.05)。结论:FOLFOX 4方案治疗晚期胃癌效果与FLP化疗方案相当,但是其毒副反应轻,患者生存质量改善更佳,可以作为胃癌晚期患者的化疗方案在临床上推广使用。
Objective：To observe the chemotherapy efficacy and toxic side effects of FOLFOX 4 and FLP regimen on patients with advanced gastric cancer. Methods：117 patients with advanced gastric cancer, who were confinned by pathological diagnosis, were enrolled between January 2011 and September 2012 in our hospital. FOLFOX 4 regimen was consisted of oxaliplatin （ L-OHP） 85mg/m2 （iv） on the first day （ d1 ） ; fluorouracil （ 5 - FU） 400mg/m2 iv bolus, 600mg/m2 （ continuous iv） for 22h, d1-2 ; leucovorin （LV） 200mg/m2 infusion 2h, d1-2 ; 3 weeks as 1 cycle. FLP regimen included cisplatin （DDP） 30mg/m2 infusion, d1_3; 5 -FU 500 mg/m2 intravenous infusion for 4 hours, d1-5; LV 200rag/m2 infusion 2h, d1-5; 3 weeks as 1 cycle. Complete remission and the incidence of toxicity were compared between the two regimens. Results：The total effective rate of 55.17% for FOLFOX 4, 52.54% for FLP, there was no significant difference （P 〉0.05） between the both regimens, no difference in functional status as well. The occurrence of neurotoxicity in FOLFOX 4 was easier than that in FLP, but incidence of nausea and vomiting was significantly lower than that in FLP （ P 〈 0.05 ）. Conclusions： Chemotherapy efficacy of FOLFOX 4 regimen approximates FLP regimen but toxicity of FOLFOX 4 was lighter than that of FLP regimen.
出处
《青海医药杂志》
2013年第3期4-7,共4页
Qinghai Medical Journal
