美沙拉嗪联合灌肠治疗溃疡性结肠炎的疗效探讨

目的探讨美沙拉嗪联合灌肠治疗溃疡性结肠炎的临床疗效。方法选取2008年3月-2012年5月广德县人民医院收治的溃疡性结肠炎患者70例,随机分为两组,各35例。观察组口服美沙拉嗪缓释颗粒,同时给予美沙拉嗪灌肠剂;对照组采用柳氮磺胺吡啶进行治疗。参考相关疗效判定,记录两组患者疗效及不良反应发生率。结果观察组总有效率97.1%,对照组82.9%,差异有统计学意义(P<0.05);观察组不良反应发生率2.9%,对照组不良反应发生率22.9%,差异有统计学意义(P<0.05)。结论美沙拉嗪口服联合灌肠治疗对溃疡性结肠炎疗效显著,不良反应发生率较低,值得临床推广应用。

Objective To explore the efficacy of mesalazine combine enema in the treatment of ulcerative colitis.Methods 70 cases of patients with ulcerative colitis accessed to our hospital from March 2008 to May 2012 were selected as objects.They were randomly divided into two groups,35 cases in the treatment group and 35 cases in the control group.Mesalazine SR granules and mesalazine were given to the treatment group.Sulfasalazine were given to the control group.The efficacy of two groups were recorded which was refer to Zhang Yanling＇s standard.Results The total effective power of treatment group（97.1%） was obviously higher than that of control group（82.9%）,the difference was statistically significant（P 0.05）.The adverse reaction ratio of treatment group was 2.9% and control group was 22.9%,the difference was statistically significant（P0.05）.Conclusion Mesalazine combine enema has a great effect in the treatment of ulcerative colitis and the adverse reaction ratio was lower.So we think that it is worthy to be widely spread in clinic.