咪达普利治疗老年高血压病的疗效与安全性

目的以卡托普利作对照,对比观察咪达普利对老年高血压病的疗效与安全性。方法选择符合条件的原发性老年高血压患者200例,随机分为A、B两组,A组(n=80)口服卡托普利片25mgtid;B组(n=120)口服咪达普利片10mg,qd,共4周。记录两组用药前后1、2、3、4周的血压与心率,比较用药前后的血、尿常规与生化指标,复查眼底、心电图、彩超、胸透等,以了解靶器官受累情况。结果 A、B两组患者治疗结束后,显效、有效、总有效率分别为68.75%、13.75%、82.50%、71.67%、14.17%和85.83%。A组治疗2周与B组治疗1周后各时点血压值与治疗前比较均有显著下降(P<0.05)。服药4周后,两组无明显差异(P>0.05)。两组治疗前后心率变化比较,差异无统计学意义(P>0.05)。不良反应发生情况:A组21例(构成比为26.25%),B组11例(构成比为9.17%)。结论咪达普利治疗老年高血压与7.5倍剂量的卡托普利的降压效果相近,不良反应更少,患者依从性和安全性更高。

Objective To observe the curative effect and safety of imidapril in elderly patients with hypertension,compared with captopril.Methods 200 patients with primary hypertension were averagely randomized into two groups.Captopril was taken orally in Group A,25 mg three times every day in four weeks.Meanwhile,imidapril was used 10 mg in Group B,one a day.Record the blood pressure and heart rate before and after drug 1,2,3,4 weeks,and compare blood routine examination,routine urianlysis,biochemical indicators.Results The effective rate in Group A was 82.50%,and 85.83% in Group B.The blood pressure after two weeks treatment in Group A and one week in Group B decreased obviously（P0.05）.The differences between two groups after four weeks treatment were not statistically significance（P0.05）.The heart rate in two groups had no obvious change before and after treatment（P0.05）.The adverse effects rate in Group A was 26.25%,and 9.17% in Group B.Conclusion The effects of imidapril and captopril are similar in elderly patients with hypertension,but imidapril has less adverse effects.