摘要
目的 探讨N末端脑钠肽前体(NT-proBNP)及超敏C反应蛋白(hs-CRP)对急性冠状动脉综合征(ACS)的诊断价值及相关性.方法 选取108例ACS患者(ACS组)和84例健康体检者(对照组)作为研究对象,其中非ST段抬高型心肌梗死(NSTEMI) 37例(NSTEMI组),ST段抬高型心肌梗死(STEMI) 35例(STEMI组),不稳定型心绞痛(UA) 36例(UA组),观察并比较各组血清NT-proBNP及hs-CRP水平,并进行相关性分析.结果 ACS组患者血清NT-proBNP、hs-CRP明显高于对照组[(1264.8±671.8) ng/L比(337.0±10.6) ng/L,(15.42±8.03) mg/L比(6.92±0.59) mg/L],差异有统计学意义(P<0.05).hs-CRP和NT-proBNP呈显著正相关(r=0.46,P< 0.05).NSTEMI组、STEMI组、UA组及对照组血清NT-proBNP组间比较差异均有统计学意义(P<0.05);NSTEMI组、STEMI组、UA组患者血清hs-CRP均显著高于对照组,差异有统计学意义(P〈0.05),但STEMI组与UA组比较差异无统计学意义(P>0.05).随着冠状动脉病变支数的增加,患者血清NT-proBNP和hs-CRP水平亦随之升高,差异有统计学意义(P<0.05).结论 联合检测NT-proBNP和hs-CRP可以对ACS做出早期诊断,并可作为评估预后和危险分层的重要参考指标.
Objective To evaluate the levels of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP),high sensitive C-reactive protein (hs-CRP) and the correlation in the patients with actue coronary syndrome (ACS).Methods One hundred and eight patients with ACS as ACS group,while 84 healthy controls as control group.ACS group included non-ST-segment elevation myocardial infarction (NSTEMI) group (37 cases),ST-segment elevation myocardial infarction (STEMI) group (35 cases),unstable angina(UA) group(36 cases).Recorded and compared the levels of NT-proBNP and hs-CRP in two groups,and the correlation was analyzed.Results The levels of NT-proBNP and hs-CRP in ACS group were significantly higher than those in control group [(1264.8 ±671.8) ng/L vs.(337.0 ± 10.6) ng/L,(15.42 ± 8.03) mg/L vs.(6.92 ± 0.59) mg/L,P 〈 0.05].The correlation between hs-CRP and NT-proBNP level was positive in ACS (r =0.46,P 〈 0.05).The levels of NT-proBNP in NSTEMI group,STEMI group,UA group,control group,differences among groups were statistically significant (P 〈 0.05).The levels of hs-CRP in NSTEMI group,STEMI group,UA group were significantly higher than those in control group (P 〈 0.05).There was no statistically significant difference in the levels of NT-proBNP between STEMI group and UA group (P 〉0.05).And the levels of NT-proBNP and hs-CRP increased with the increasing of coronary artery lesion counts,the differences among groups were statistically significant (P 〈0.05).Conclusion ACS can be early diagnosed through combined detection of NT-proBNP and hs-CRP,and NT-proBNP and hs-CRP can be used as important makers to evaluate prognosis and risk stratification.
出处
《中国医师进修杂志》
2013年第21期37-39,共3页
Chinese Journal of Postgraduates of Medicine
关键词
C反应蛋白质
急性冠状动脉综合征
脑钠肽
C-Reactive protein
Acnte coronary syndrome
Brain natriuretic peptide