P53、Grb7在胃肠道间质瘤中的表达及临床意义

Clinical significance of P53、Grb7 expression in gastrointestinal stromal tumor

目的探讨P53、Grb7在胃肠道间质瘤(GIST)中的表达及其与GIST生物学行为的关系,为预测该肿瘤的侵袭潜能提供理论依据和可能的预测指标。方法收集58例手术切除的GIST标本,应用免疫组织化学法检测肿瘤组织中P53和Grb7蛋白的表达,并结合病理形态学及生物学行为评价进行统计学分析。结果肿瘤组织中的P53、Grb7阳性率分别为85.2%、83.3%,并随着GIST恶性分级的增高,其表达均出现递增趋势,差异有显著性意义(P<0.05);与生长方式、肿瘤大小、肿瘤中心有无坏死、肿瘤细胞特殊排列结构亦有明显关系(P<0.05)。结论 P53、Grb7蛋白表达与GIST的发生、发展有关,检测P53、Grb7表达结合特殊病理学形态可以作为评价GIST生物学行为及预后的客观指标。

Objective To investigate the expression of P53,Grb7 protein in gastrointestinal stromal tumor（GIST）,and discuss the relationship between their expression and clincopathological characteristics. Methods 58 cases of GIST,were studied for P53,Grb7 by immunohistochemical staining,Their relations with histomor-phology and biological behavior were analyzed statistically.Results The positive expression of P53, Grb7 was 85.2%（46/54）,83.3%（43/54） respectively.The express-ion of P53,Grb7 increased significantly according to the malignant increasing（P0.05） and associated with nuclear division、the histological grade、high cellularity、nuclear pleomorphism、tumor necrosis、tumor invasion and perivascular collar-like pattern（P0.05）.Conclusion These data shows the expression of p53 and Grb7 and the clinical pathologic characteristics of GISTs are related to the biological potential,grading criteria and progression of GIST,we can provide scientific basis for the therapy and prognosis evaluation of the GISTs.p53,Grb7 in GIST.