亚低温治疗对院内心脏骤停心肺复苏后患者脑复苏的影响分析

The Curative Effect of Mild Hypothermia Therapy on Brain Recovery of Patients with Cardiac arrest After Cardiopulmonary Resuscitation(CPR)

目的探讨亚低温治疗对心肺复苏后患者脑复苏的临床疗效。方法采用回顾性资料对照研究方法。收集2006年01月至2012年10月我院ICU收治的院内心搏骤停、行心肺复苏成功的患者33例,完全随机分配常温治疗组16例与亚低温治疗组17例(中心体温降至32～34℃,维持24h),比较两组患者自主循环恢复后初始血乳酸水平,6h、24h血乳酸清除率,24h、72h、7d的G.C.S评分及APACHEⅡ评分。结果在CPR术后7d,接受亚低温治疗患者的G.C.S评分明显高于常温治疗组,24h血乳酸清除率在亚低温治疗组亦高于常温治疗组,亚低温治疗组的APACHE评分低于常温治疗组。结论亚低温治疗有促进心肺复苏自主循环恢复患者脑功能的改善及降低病死率的作用。

Objective To investigate the clinical efficacy of mild hypothermia therapy after cardiopulmonary resuscitation in patients with cerebral resuscitation. Methods Retrospective data control study method. Collected from January 2006 to October 2012 ICU of our hospital admitted to hospital cardiac arrest, 33 patients with successful cardiopulmonary resuscitation in line, completely randomly assigned to room temperature treatment group, 16 patients with treatment group, 17 cases of mild hypothermia （core temperature drops 32-34 ＊C, maintain 24h）, after the initial blood lactate levels were compared in patients with return of spontaneous circulation, 6h, 24h blood lactate clearance, 24h, 72h, 7d GCS score and APACHE II score. Results In CPR postoperative 7d accept the hypothermia treatment in patients with GCS score was significantly higher than the normal temperature treatment group, the 24h blood lactate clearance rate in the hypothermia-treated group was also higher than normal temperature treatment group, the hypothermia treatment group the APACHE II score lower than room temperature treatment group. Conclusions Mild hypothermia therapy to promote cardiopulmonary resuscitation restoration of spontaneous circulation to improve and reduce the role of the mortality of patients with brain function.