妊娠妇女血清IGF-1及IGFBP-1浓度与其新生儿出生体质量的相关性研究

Pregnant Women Serum Concentrations of Igf-1 and IGFBP 1 with Neonatal Birth Weight the Relevance of Research

目的研究新生儿脐血中胰岛素样生长因子-1(IGF-1)以及其结合蛋白(IGFBP-2)水平,分析IGF-1,IGFBP-1同妊娠期高血压病以及新生儿出生体质量的关系。方法选择我院2010年5月至2012年9月共109例妊娠孕妇作为研究对象,其中正常孕妇20例,轻度子痫前期孕妇35例,重度子痫前期孕妇44例,采用放射免疫法检测脐带血IGF-1,IGFBP-1的水平,随访至分娩。观察孕妇血清IGF-1,,IGFBP-1水平与新生儿出生结局的相关性。结果妊娠期高血压病患者脐带血IGF-1与新生儿体质量呈明显正相关,IGFBP-1与新生儿体质量呈负相关,且IGF-1较正常组孕妇低,IGFBP-1水平较正常组孕妇高两者存在负相关。结论妊娠期孕妇血清游离IGF-1水平对胎儿的生长具有重要作用,是反映胎盘功能的早期信号,是发生高血压结局的信号,所以测定IGF-1,IGFBP-1有利于较早预防高血压病情的轻重。

Objective To study the neonatal umbilical cord blood of insulin-like growth factor 1 （igf-1） and its binding protein （1GFBP - 2） level, the analysis of the IGF - 1, IGFBP 1 with gestational hypertension and the relationship between neonatal birth weight. Methods From May 2010to September 2012, a total of 109 cases of pregnancy pregnant women as the research object, including 20 cases of normal pregnant women, a mild preeclampsia women 35 eases, 44 cases of severe preeclampsia in pregnant women, the ria method of detecting cord blood IGF - 1, IGFBP 1 level, follow-up to delivery. Observation of pregnant women serum IGF - 1, IGFBP 1 levels and birth outcome relevance. Results Gestational hypertension patients with neonatal cord blood IGF - 1 body weight was significantly positive correlation, IGFBP 1 and negatively correlated with birth weight, and igf-1 was lower than those of normal group of pregnant women, IGFBP 1 level higher than normal group of pregnant women is negatively related to both. Conclusion Pregnancy pregnant women serum free igf-1 level plays an important role in the growth of the fetus, and is an early sign of the placenta function, is high blood pressure end of the signal, so the determination of IGF - 1, IGFBP 1 is conducive to early prevention of hypertension illness severity.