喉鳞状细胞癌组织中IL-17的表达及其临床意义

Expression of IL-17 in laryngeal squamous cell carcinoma tissues and the clinical significance

目的:检测喉鳞状细胞癌组织中IL-17的表达情况,评价IL-17的表达在喉鳞状细胞癌生物学行为和预后中的价值。方法:采用免疫组化SP法检测71例喉鳞状细胞癌及21例癌旁组织中IL-17的表达。结果:喉鳞状细胞癌组织中IL-17的表达率为54.9%(39/71),与癌旁组织(28.6%)对比差异有统计学意义(P<0.05);IL-17的表达与喉癌的分期、肿瘤分化、区域淋巴结转移、远处转移及复发有关(均P<0.05);Log-rank检验显示患者预后与肿瘤原发灶部位、原发灶分期、区域淋巴结转移、远处转移、IL-17的表达有关(P<0.05),多因素Cox回归分析发现IL-17不是影响患者预后的独立危险因素。结论:IL-17与喉鳞状细胞癌的发生、发展以及预后关系密切,是喉鳞状细胞癌患者的不良预后因素,可为喉鳞状细胞癌的抗肿瘤免疫治疗提供一定的理论依据。

Objective：To investigate the expression of interleukin 17 in laryngeal squamous cell carcinoma tissues,and to evaluate the value of interleukin-17 in the biological behavior and prognosis of laryngeal squamous cell carcinom.Method：Expressions of IL-17 were analyzed in 71 laryngeal squamous cell carcinoma samples and 21 cases of adjacent tissues of carcinoma as control by immunohistochemistry.Result： The expression of IL-17 in laryngeal squamous cell carcinoma tissues was obviously higher than that in adjacent tissues（P 0.05）.The expression of IL-17 was associated with tumor T staging,tumor differentiation,regional lymph node metastasis,distant metastasis and recurrence（P 0.05）.Log-rank test showed that the prognosis of patients was related to the primary tumor site,tumor stage,regional lymph node metastasis,distant metastasis and IL-17 expression（P 0.05）,While Cox multiple factors analysis showed that IL-17 was not an independent prognostic factors.Conclusion： The expression of IL-17 may be the vital index in laryngeal squamous cell carcinoma,and it can provide some theoretical basis for the anti-tumor immunotherapy for laryngeal squamous cell carcinoma.