儿童反复呼吸道感染与甘露聚糖结合凝集素、胰岛素样生长因子-1和锌缺乏的关系

Serum Levels of Mannose-Binding Lectin,Insulin-Like Growth Factor-1,and Zinc in Relation to Recurrent Respiratory Tract Infections of Children

目的:探讨甘露聚糖结合凝集素(MBL)、胰岛素样生长因子-1(IGF-1)和锌缺乏与儿童反复呼吸道感染的关系。方法:46例反复呼吸道感染儿童作为观察组,32例健康儿童作为对照组。对两组MBL、IGF-1和血锌水平进行测定。结果:观察组与对照组MBL、IGF-1及血锌相比分别降低,有统计学差异(P<0.01),同时MBL、IGF-1及血锌水平呈正相关(P均<0.05)。结论:儿童反复呼吸道感染的内在因素是免疫功能低下、紊乱,而血中MBL、IGF-1及锌显著降低,是造成儿童反复呼吸道感染主要原因之一,监测其变化对儿童反复呼吸道感染的诊治有重要意义。

Objective. To explore the relationship among the serum levels of mannose-binding lectin （MBL） and insulin-like growth factor-1 （IGF-1）, amang zinc deficiency and recurrent respiratory tract infection in children. Methods. The serum MBL, IGF-1, and zinc levels of 46 children with recurrent respiratory tract infections were compared with those of 32 healthy children. Results. All the three indices were lower than that respectively in control group （all P%0.01）, and the serum zinc levels were positively correlated to the levels of MBL and IGF-1. Conclusion.- Serum MBL, IGF-1, and zinc levels were decreased determination of these indices might help for in recurrent respiratory tract infection children, and the diagnosis and treatment of such patients.