人乳头状病毒(HPV)与口咽癌相关性的研究进展

Progress on role of human papilloma virus(HPV) in oropharyngeal cancer

近年来,研究表明口腔癌的发病率总体呈下降趋势,但口咽癌的发病率却有显著增长的趋势,而且越来越多的研究表明人乳头状病毒(human papilloma virus,HPV)在口咽癌的发病及临床诊断、预后及防治中均扮演着重要的角色,使得HPV阳性的口咽癌呈现出与HPV阴性口咽癌不同的特征,这在国内外科研中受到广泛的关注。本文将对HPV与口咽癌的相关性研究的进展作一综述。

In recent years,there has been an overall decrease in cancers of the oral cavity,whereas the incidence rate of oropharyngeal carcinoma has increased substantially. More and more evidences showed that human papilloma virus （HPV） may play an important role in the development of oropharyngea squamous cell carcinoma, including the cancer incidence, treatment, prognosis and prevention and so on. And it receives widespread attentions in the international scientific research. This review focuses on the association between HPV and oropharyngeal cancer.