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TWIST基因甲基化在肿瘤发生发展中的研究进展 被引量：1

Advance in the study on TWIST promoter methylation in tumor development
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摘要 TWIST基因属于碱性螺旋-环-螺旋(bosic Helix-Loop-Helix farily,bHLH)转录因子家族成员之一,在多种种属的基因组中高度保守并调控胚胎发育。该基因的功能包括参与上皮-间质转变(epithelial-mesenchymal transition,EMT)、抗细胞凋亡、促进肿瘤血管生成和导致染色体不稳定等,但是其在肿瘤发生发展中的调节机制仍不清楚。近年来,大量文献报道证实了表观遗传学为肿瘤发病重要机制之一,其中TWIST基因启动子的高甲基化与肿瘤的发生、进展以及临床病理特征都有关系,本文就此作一综述。 TWIST gene belongs to the basic-helix-loop-helix family （bHLH） of transcription factors,which is highly conserved and involved in embryonic development. TWIST can regulate the epithelial-mesenchymal transition （EMT）, inhibit apoptosis, induce angiogenesis and chromosomal instability, but there is little known about the mechanism of regulating tumors. From recent years, there has been lots of reports that epigenetic is an important mechanism in the development of tumor, in which TWIST promoter hypermethylation has a relation with tumors development and clinipathologocal features, and so on.
作者 高峰 薛明明 尹化斌
机构地区 复旦大学附属上海市第五人民医院放射科 复旦大学附属中山医院急诊科
出处 《复旦学报（医学版）》 CAS CSCD 北大核心 2013年第4期486-490,共5页 Fudan University Journal of Medical Sciences
关键词 TWIST基因 甲基化 肿瘤 TWIST gene methylation tumor
分类号 R730.231 [医药卫生—肿瘤]
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参考文献34

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复旦学报（医学版）
2013年 第4期

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