我国儿童及母亲孕期接触农药与儿童白血病关系的Meta分析

A meta-analysis on relationship between children and pregnant mothers' pesticides exposure and childhood leukemia in China

目的探讨我国儿童及母亲孕期接触农药与儿童白血病的关系。方法对检索国内外数据库得到的12篇关于我国儿童及母亲孕期接触农药与儿童白血病关系的文献进行Meta分析。结果儿童及母亲孕期接触农药可增加儿童患白血病的风险（OR：2．28，95％CI：2．01～2．59）。按照地区、对照来源、样本量、调查时间、接触方式进行分组，亚组分析结果显示，各亚组儿童及母亲孕期接触农药均可增加儿童患白血病的风险。结论儿童及母亲孕期接触农药是儿童白血病的危险因素。

Objective To investigate the relationship between Chinese children and pregnant mothers＇ pesticides exposure and childhood leukemia. Methods Databases were searched and 12 relevant published articles were got finally. Meta analysis was performed after extract data of included literatures. Results Children and pregnant mothers＇ pesticides exposure could increase the risk of childhood leukemia （OR =2.28,95% CI：2.01-2.59）. Area, sources of control groups, sample size, investigation time and contact mode were set as the grouping factors, the results showed that each group of children and pregnant mothers exposed to pesticides could increase the risk of childhood leukemia. Conclusion Children and pregnant mothers pesticides exposure is a risk factor for childhood leukemia.