阿魏酸薄荷酯的合成与体外总抗氧化能力

Synthesis and Measuring Total Antioxidant Ability in vitro of Menthyl Ferulate

目的:研究阿魏酸薄荷酯的合成方法及其体外总抗氧化能力。方法:以香兰素为原料,通过与中间体丙二酸单薄荷酯发生缩合反应合成阿魏酸薄荷酯,并通过法和铁离子还原(FRAP)法对其总抗氧化能力进行了测定。结果:经过三步反应合成得到了阿魏酸薄荷酯,化合物未见报道,结构经1H-NMR和MS得到确证,在试验浓度范围内具有一定的抗氧化能力,但比阿魏酸弱。结论:阿魏酸薄荷酯具有抗氧化活性,其合成方法适用于其他阿魏酸酯或阿魏酸酰胺衍生物的合成。

Objective： To study synthesis and total antioxidant ability in vitro of menthyl Ferulate.Method： The vanillin was used as raw material and menthyl hydrogen malonate was used as intermediate,condensation reaction between them was used to synthesize menthyl ferulate,and the ferric reducing ability of plasma（FRAP） method was used to measure its total antioxidant ability in vitro.Result： Menthyl ferulate was obtained through three steps reaction route,this compound has not reported,its structure was confirmed by 1HNMR and MS.Menthyl ferulate showed the antioxidant ability in the trial concentration range,but weak than ferulic acid.Conclusion： Menthyl ferulate has antioxidant activity,the synthetic method is applicable to other ferulic acid ester or ferulic acid amide derivatives.