喘平方在大鼠与人体内药代动力学参数比较

Comparative Analysis of in vivo Pharmacokinetic Parameters of Chuanping Compound in Rats and Human

目的:比较喘平方在大鼠与人体内药代动力参数。方法:采用HPLC测定SD大鼠血液与人尿中麻黄碱和伪麻黄碱质量浓度,通过3P87软件计算大鼠血液中药动学参数,尿药亏量法计算人尿中药动学参数。结果:喘平方在大鼠体内与人体内药代动力学参数不尽相同。复方中麻黄与洋金花相互作用对麻黄碱、伪麻黄碱在大鼠体内的代谢无明显影响,但对2种成分在人体内代谢有影响,结论:药物高剂量给药在动物体内代谢过程与正常服用剂量在人体内代谢过程存在差异,动物高剂量给药试验不能如实反映药物在人体内代谢过程。

Objective： To compare in vivo pharmacokinetic parameters of Chuanping compound in rats and human.Method： HPLC was adopted for determining the concentration of ephedrin and pseudoephedrine in SD rats blood and human urine,pharmacokinetic parameters in rats blood and human urine were calculated by 3P87 software and urine drug deficiency,respectively.Result： Pharmacokinetic parameters of chuanping compound in rats and human were not the same,interaction of Ephedra sinica and Datura metel had no significant effect on metabolism of ephedrin and pseudoephedrine in rats,but it had influence in human.Conclusion： Metabolic process was different between drugs with high dosage in animals and drugs with normal dose in human.In vivo metabolic process of animals with high dosage could not accurately reflect drugs in human.