肺癌相关内源性激素及其受体研究进展

Research Progress of Lung Cancer Related to Endogenous Hormone and its Receptor

查阅近年来有关肺癌相关内源性激素及其受体研究的文献,将整理与肺癌密切相关的几种内源性多肽类激素如血管紧张素及其受体、雌激素及其受体、胰岛素样生长因子及其受体、生长抑素及其受体与胸腺激素等进行综合分析。结果显示调节肺癌的发生和发展与内源性激素调节紊乱有一定的关系,血管紧张素及其受体、雌激素及其受体、胰岛素样生长因子及其受体、生长抑素及其受体、胸腺激素均有抑制肺癌生长的作用。寻找和设计抗肺癌药物乃至抗肿瘤药物,内源性寡肽类激素及其类似物将是一个重要的考虑方向。研究与肺癌发生和发展相关的内源性激素及其调控网络,对于设计和研发抗肺癌药物具有及其重要的参考价值。

This paper reviews recent endogenous small molecule peptide-hormone and its analogues,and the occurrence of lung cancer and the development of relations involved in the mediation of the body’s physiological and biochemical functions.Traditional cytotoxic anticancer drugs in lung cancer chemotherapy in the treatment of tumors,normal vital organs of the human body and cause serious toxicity in the pathogenesis of lung cancer and the cause has not been fully elucidated,you need to find one within the derived low toxicity,readily biodegradable anticancer drugs,such as small molecule peptide-hormones and their analogues has become the research focus in recent years.Accordingly this article endogenous polypeptide hormone summarized to provide a reference for the latter part of the design and development of anticancer drugs.