黄连素结合三联疗法根除幽门螺杆菌感染的临床效果观察

Clinical aurative effect observation of berberine combined with triple therapy in eradicating helicobacter pylori infection

目的探讨黄连素联合三联疗法治疗幽门螺旋杆菌感染相关性胃炎及消化性溃疡的临床疗效。方法选择本院2012年至2013年90例消化性溃疡患者的资料,随机分为观察组和对照组,各45例,其中对照组采用三联疗法;观察组患者在此基础上加用黄连素,治疗时间都是2周。治疗结束4周后,溃疡患者复查胃镜,观察Hp感染情况和溃疡愈合程度;胃炎患者复查13C-尿素呼气试验,观察Hp根除率。同时观察患者的不良反应。结果观察组患者Hp清除率高,不良反应发生率低,总有效率高,两组比较差异有统计学意义(P<0.05)。结论黄连素联合三联疗法治疗幽门螺旋杆菌感染,临床效果满意,值得在临床推广应用。

Objective To investigate berberine combined triple therapy of Helicobacter pylori infectionassociated gastritis and peptic ulcer clinical efficacy.Methods From 2012 to 2013,90 cases of patients with peptic ulcer data were randomly divided into observation group and control group,45 cases in the control group were treated with triple therapy;observation group took berbrine combined with triple therapy the treatment time was two weeks.Four weeks after the end of treatment,ulcer patients endoscopy to observe Hp infection and ulcer healing degree;gastritis review the 13C-urea breath test,Hp eradication rate was observed.Also observed adverse reactions in patients.Results The patients Hp clearance rate,a low incidence of adverse reactions,the total effective rate,the difference was statistically significant（P〈0.05）.Conclusion The combination of berberine triple therapy Helicobacter pylori infection,the clinical results were satisfactory,worthy of clinical application.