摘要
1型糖尿病是一种器官特异性自身免疫性疾病。其发病机制复杂，在遗传、环境、免疫等诸多因素的共同作用下，自身抗原免疫耐受丧失，免疫调节失衡，导致针对胰岛β细胞的自身免疫性破坏，导致糖尿病的发生。但其具体病因目前尚不明确，再生基因家族、胰．十二指肠同源盒因子1、嗜铬粒蛋白A、辅助性T细胞（Th）17及胰岛稳态蛋白等均参与1型糖尿病发病的不同环节，同时这些新的免疫学因子的发现，为1型糖尿病的诊断及治疗提供了新的靶点。
Type 1 diabetes mellitus is an organ-specific autoimmune disease. Its pathogenesis is complex. Under the interaction of genetic, environmental and immune factors, autoantigen immune tolerance is lost, immune regulation is imbalance, which lead to the autoimmune destruction of pancreatic beta cells, thus lead to the occurrence of diabetes. But the specific cause is unclear. Regenerative gene, pancreas and duode-nal homeobox gene 1 ,ehromogranin A,Th17 and islet homeostasis protein may involve in the development of type 1 diabetes mellitus. And flew immunological factors will provide new therapeutic targets of type 1 diabe-tes mellitus.
出处
《国际内分泌代谢杂志》
北大核心
2013年第4期247-249,共3页
International Journal of Endocrinology and Metabolism
