兽医生理模型研究进展
摘要
生理模型以其独特的优越性和广阔的应用前景，引起国内外研究者的广泛关注，并开展了大量的实验研究。生理模型具有以下特点：（1）可模拟器官或组织内药物原型及其代谢物浓度的经时变化过程；（2）可研究和预测病理或药理因素对药物体内过程的影响；（3）可实现不同暴露状况下，暴露剂量、暴露途径和暴露方案之间的外推。
出处
《广东畜牧兽医科技》
2013年第4期6-8,共3页
Guangdong Journal of Animal and Veterinary Science
参考文献15
-
1Duddy J, Hayden T L, Bourne D W, et al. Physiological model for distribution of sulfathiazole in swine[J]. J Pharm Sci, 1984,73(11):1525-1528.
-
2Horkovics-Kovats S, Schatz F. Physiologically based pharmacokinetic modelling with valnemulin and its metabolites after multiple oral administration in pigs[J].J Pharm Med, 1996(6):149-167.
-
3Buur J L, Baynes R E, Craigmill A L, et al. Development of a physiologic-based pharmaeokinetic model for estim- ating sulfamethazine concentrations in swine and app- lication to prediction of violative residues in edib- le tissues[J].AmJ Vet Res, 2005,66(10):1686-1693.
-
4Buur J, Baynes R, Smith G, et al. Use of probabilistic modeling within a physiologically based pharmacoki- netic model to predict sulfamethazine residue with- drawal times in edible tissues in swine[Jl. Antimic- rob Agents Chemother, 2006,50(7):2344-2351.
-
5Yang B, Huang L L, Fang K, et al.A physiologically based pharmacokinetic model for the prediction of the dep- letion of methyl-3-quinoxaline-2-carboxylic acid the marker residue of olaquindox, in the edible tissues of pigs[J].J Vet Pharmacol Therap, 2Ol3, DOI:10. 1111/ jvp. 12053.
-
6Yang F, LiuHW, Li M, et al.Use of a Monte Carlo analysis within a physiologically based pharmacokinetic model to predict doxycycline residue withdrawal time in edible tissues in swine[J].Food Additives & Conta- minants:Part A. 2012,29(I):73-81.
-
7Yang F, Huang X H, Li G H, et al. Estimating tulathrom- ycin withdrawal time in pigs using a physiological- ly based pharmacokinetics model[JJ.Food Additives & Contaminants:Part A. 2013, DOI:10. 1080/19440049.2013. 797113.
-
8Brocklebank J R, Namdari R, Law F C.An oxytetracycline residue depletion study to assess the physiologic- ally based pharmokinetic(PBPK) model in farmed At- lantic salmon[J].Can Vet 3,1997,38(10):645-646.
-
9Yang F, Sun N, Sun Y X, et al.A physiologically based pharmacokinetics model for florfenicol in crucian carp and oral-to-intramuscular extrapolat Vet Pharmacol Therap, 2013,36(2):192-200.
-
10Craigmill A L.A physiologically based pharmacokin- etic model for oxytetracycline residues in sheep [J].J Vet Pharmacol mher, 2003,26(1):55-63.
-
1李慧民,孔涛.纳米氧化锌对生物体的毒性及其机制[J].中国兽医学报,2016,36(9):1643-1647. 被引量：2
-
2罗显阳.泰拉霉素在兔体内的药动学预测[J].广东畜牧兽医科技,2013,38(5):32-35. 被引量：5
-
3罗显阳,朱理想,王蕊,余军军,远立国.土霉素生理药物代谢动力学模型的种间类推[J].黑龙江畜牧兽医,2010(5):112-113.
-
4王林,丁焕中.生理模型在兽医药物动力学研究中的应用[J].中国畜牧兽医,2011,38(3):47-50. 被引量：1
-
5唐仕华.椰子生长生理模型的研究[J].世界热带农业信息,2002,0(1):18-19.
-
6摘下的蔬菜为何还能长？[J].科技信息（山东）,2014(5):102-102.
-
7湛嘉,李佐卿,康继韬,俞雪均,谢东华,孙大为,杨先乐.影响水产动物药代动力学的因素[J].中国兽药杂志,2003,37(12):38-41. 被引量：15
-
8罗显阳,赵全成,李小娜,史丽娜,梁军.蒙特卡洛联合生理模型在兽药残留研究中的应用[J].中国兽医杂志,2014,50(1):57-59. 被引量：3
-
9王蓓蕾,蒋煜峰,朱琨.水环境中抗生素的研究进展[J].农业与技术,2012,32(4):158-159. 被引量：3
-
10丁焕中,曾振灵.生理药动学模型及其在兽医药理学研究中的应用[J].动物医学进展,2007,28(9):55-59. 被引量：8
