利巴韦林联合喜炎平治疗小儿手足口病的临床疗效

Efficacy of combination therapy of ribavirin and xiyanping on hand-foot-mouth disease

目的探讨利巴韦林联合喜炎平治疗手足口病的临床疗效。方法 2012年4—7月收治手足口病普通病例186例,将其随机分为两组,治疗组96例,对照组90例。对照组予以利巴韦林10 mg/(kg.d)静脉滴注,治疗组在对照组的基础上加用喜炎平注射液5～10 mg/(kg.d)静脉滴注,均为1次/d,疗程7 d。观察两组患儿治疗后的效果、住院时间和不良反应等情况。结果治疗组总有效率为92.71%(89/96),对照组为68.89%(62/90),两组比较,差异有统计学意义(χ2=7.98,P<0.05)。治疗组的退热时间、皮疹消退时间、口腔溃疡愈合时间和住院时间分别为(2.51±1.12)d、(2.68±0.82)d、(3.78±1.23)d、(4.82±1.48)d,均较对照组[分别为(4.29±1.61)d、(3.89±1.33)d、(4.91±1.77)d、(7.12±1.89)d]明显缩短,差异有统计学意义(t值分别为8.80、6.40、5.08、9.27,均P<0.05)。结论利巴韦林联合喜炎平治疗手足口病普通病例有较好的临床疗效,无明显不良反应。

Objective To evaluate the efficacy of combination therapy of ribavirin and xiyanping on the treatment of hand-foot-mouth disease （HFMD）. Methods From April to July 2012, one hundred and eighty-six cases of HFMD admitted to a hospital were randomly divided into two groups, 90 patients in control group received ribavirin intravenous drip （10 mg/kg· d）, and 96 patients in treatment group added xiyanping intravenous drip （5- 10 mg/ kg · d） in addition to ribavirin,all were once a day for 7 days. The efficacy, length of hospital stay, and adverse re- actions and so on in two groups were observed after treatment. Results Total efficacy rate was 92. 71% （89/96）in treatment group and 68. 89 % （62/90）in control group（z2 = 7. 98, P〈0. 05）. Defervescence time, deflorescence time, oral ulcer healing time and length of hospital stay in treatment group were significantly shorter than those in control group（12. 51-± 1.12] d vs [4. 29 ± 1.61]d,t = 8. 80; [2. 68 ± 0. 82] d vs [3. 89 ± 1.33]d,t = 6. 40; [3. 78 ± 1.23]d vs [4. 91 ±1. 77]d,t= 5. 08; E4. 82 ±- l. 48]d vs [7.12 ± l. 89]d,t =9. 27 ;all P〈0.0O5）. Conction Thecombination of ribavirin and xiyanping has a better clinical efficacy on ordinary cases of HFMD, and adverse reaction is little.