强迫症患者认知功能与儿茶酚氧位甲基转移酶基因多态性的关系

Relationship Between Cognitive Function and COMT Gene Polymorphism in OCD Patients

目的探讨强迫症(OCD)患者认知功能与儿茶酚氧位甲基转移酶(COMT)基因多态性之间的关联性。方法对88名OCD患者应用PCR及RFLP技术检测COMT基因的多态性;并采用威斯康星卡片分类测试(WCST)、连线试验A和B、韦氏积木拼图子测试测评所有患者的执行功能、注意和操作智商。结果 OCD患者COMT基因多态性频率分布符合Hardy-Weinberg平衡法则(χ2=0.00,P=0.99);患者的WCST测试,连线测试A和B以及韦氏积木拼图测试在G/G、G/A、A/A三个基因型组间均无显著性差异(P>0.05)。结论 OCD患者的执行功能、注意和操作智商可能并不会受COMT基因多态性的影响。

Objective To explore the association between cognition and catechol-O-methyl transferase （COMT） gene polymorphism in patients with OCD. Methods 88 OCD patients＇ COMT gene polymorphism were tested by PCR-RFLP technique; meanwhile, Wisconsin card sorting test （WCST）, trail making test A and B （TMT A and B） and Wechsler intelligence scales： block design subtest （WISC： BD） were employed to assess executive function, attention and performance intelligence quotient. Results The distribution of COMT genotypic frequency accorded with the Hardy-Weinberg equilibrium （χ2 = 0.00, P = 0.99）. However, there was no positive association between the COMT gene polymorphism and the tests of WSCT, TMT A and B, WISC （P 〉0.05）. Conclusions The executive function, attention and performance intelligence quotient may not be influenced by the COMT gene polymorphism in OCD patients.